Functional Magnetic Resonance Imaging Investigation of the Amphetamine Sensitization Model of Schizophrenia in Healthy Male Volunteers

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Functional magnetic resonance imaging investigation of the amphetamine sensitization model of schizophrenia in healthy male volunteers.

CONTEXT Recent work suggests that the amphetamine sensitization model of schizophrenia can safely be induced in healthy volunteers and is associated both with behavioral and dopaminergic hypersensitivity to amphetamine. However, the effects of a sensitization on brain function remain unclear. OBJECTIVE To assess the impact of a sensitizing dosage regimen of dextroamphetamine on human cortical...

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ژورنال

عنوان ژورنال: Archives of General Psychiatry

سال: 2011

ISSN: 0003-990X

DOI: 10.1001/archgenpsychiatry.2011.3